During the show's first year, the focus mainly was placed upon Corky. Much of the show examined the challenges of a family whose son had Down Syndrome. In addition, during the first three seasons, episodes included Tyler Benchfield, Becca's high school crush, who also had a brother with Down syndrome. Eventually, Becca and Tyler would start a relationship.
In the third and fourth seasons the show's focus centered on Becca and a new character named Jesse. As the two became friends, Jesse told Becca he was HIV positive. Becca and Jesse began a relationship, despite his HIV, much to the surprise of those around them.