In the opening title, George is depicted swinging on vines, repeatedly slamming face-first into trees or other obstacles even as theme-song singers warn him to "watch out for that tree!" Another running gag is that George keeps forgetting that he lives in a treehouse, falling to the ground every time he leaves home.
George's two most frequent foes are a pair of hunters named Tiger and Weevil. Tiger, the taller of the two, wears a pith helmet and khakis and has a pencil moustache; while Weevil wears a white t-shirt and shorts with a hat. George's "beloved mate" is Ursula, a Jane-like character far brighter than George. George's closest friend is an ape named Ape, who speaks with a cultured British accent and, like Ursula, is far more intelligent than George. George has a pet elephant named Shep, who behaves like a lap dog or, as George refers to him, a "great big peanut-lovin' poochie," and whom George thinks is a dog.